Prophylactic Activity of a Phenanthrene Methanol (WR 33063) and a Quinoline Methanol (WR 30090) in Human Malaria
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چکیده
منابع مشابه
Treatment of falciparum malaria from Vietnam with a phenanthrene methanol (WR 33063) and a quinoline methanol (WR 30090).
Two new investigational antimalarial drugs developed by the U.S. Army Malaria Research Program were tested in patients with multi-drug-resistant falciparum malaria from Vietnam. WR 33063, a phenanthrene methanol, cured 13 patients treated in the United States. All of these patients had suffered multiple recrudescences after treatment with standard antimalarial drugs. In addition, 23 of 25 patie...
متن کاملAnti-hyperlipidemic activity of methanol extracts of three plants of Amaranthus in triton-WR 1339 induced hyperlipidemic rats
Cardio vascular diseases are leading cause of death in both industrialized and developing nations. Disorders of lipid metabolism, following oxidative stress are the prime risk factors for initiation and progression of these diseases[1]. The current anti-hyperlipidemic therapy includes principally statins and fibrates, the former corrects the altered blood lipid profile by inhibiting the bio-syn...
متن کاملLong - term photometry of the Wolf - Rayet stars WR 137 , WR 140 , WR 148 , and WR 153 ⋆
In 1991, a long term UBV -photometry campaign of four Wolf-Rayet stars was started using the 60 cm telescope of the National Astronomical Observatory Rozhen, Bulgaria. Here we report on our observational results and discuss the light variations. The star WR137 was observed during 1991 1998. No indications of eclipses were found, though random light variations with small amplitudes exist, which ...
متن کاملProduction of quinoline-2-methanol and quinoline-2-methanol acetate by a new species of Kitasatoa Kitasato griseophaeus.
Two metabolites have been isolated from the fermentation broth of a new species of Kitasatoa, Kitasatoa griseophaeus. These alkaloids have been identified as quinoline-2-methanol and quinoline-2-methanol acetate. The former exhibits hypoglycemic activity in the rat.
متن کاملFrequency of Wr(a) antigen and anti-Wr(a) in Brazilian blood donors.
BACKGROUND Wr(a) is a low-incidence antigen, which is antithetical to the high prevalence red blood cell antigen, Wr(b). Anti-Wr(a) is a naturally occurring antibody that is found in approximately 1-2% of blood donors. The aim of this study was to determine the frequency of Wr(a) and anti-Wr(a) in Brazilian blood donors. METHODS A total of 1662 Brazilian blood donors were molecularly analyzed...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1973
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.3.2.220